| ncRNA name | FAM18B siRNA |
| ncRNA Category | siRNA |
| Disease name | diabetic retinopathy (DR) |
| Species | Homo sapiens |
| Tissues/Cell_line | human retinal microvascular endothelial cells (HRMECs) |
| Methods | siRNA transfection, immunohistochemistry, immunofluorescence, qRT-PCR, Western blot, flow cytometry, tube formation assay |
| Expression pattern | associated |
| Functional description | The downregulation of FAM18B by siRNA in HRMECs results in enhanced migration and tube formation, but also exacerbates the hyperglycemia-induced decrease in HRMEC viability. The pathogenic changes observed in HRMECs as a result of FAM18B downregulation were reversed with PDTC, a specific NF-κB inhibitor. |
| PubMed ID | 25221423 |
| Year | 2014 |
| Title | Role of FAM18B in diabetic retinopathy. |
| Drug-related ncRNA | NO |
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